Compatibility is unknown between Benadryl and Ativan, do not mix. Haldol is an antipsychotic. Give it at least 10 min. Benadryl is incompatible with Haldol, do not mix. It's much safer to give all separately, even though it means 3 shots. No: Not in a hospital environment. A US doctor answered Learn more. 1995 Nov;29(11):1168-9. doi: 10.1177/106002809502901120. Incompatibility can involve precipitation, ionic reactions, evolution of gas and denaturation of biological molecules. I can't quite remember what the mixture of meds was though, I think it was 5 mg Haldol, 2 mg of Ativan and 50 mg of diphenhydramine… These two drugs are compatible in syringe and should be mixed so that only one injection is needed. It blocks dopamine in the brain. Benadryl is effective against the side effects of Haldol. Ativan is compatible with Haldol, ok to mix. Don’t use topical lorazepam (Ativan), diphenhydramine (Benadryl), and haloperidol (Haldol) (“ABH”) gel for nausea. Rationale and Comments: Just drawing up Ativan is a problem for it is thick & getting it into a syringe is a problem . The standard dose of the combination used for chemical sedation of the agitated patient is “ten and two” meaning 10mg of Haldol and 2mg of Ativan. Learn more about how mixing drugs can be a health hazard. So I remember my instructor mentioning something that he referred to as a "B52 cocktail" awhile back, it's supposedly used as a chemical restraint. Knowledge of drug compatibility is needed before mixing drugs. You can reduce this to “five and one” or … IV Drug Compatibility Chart A Alteplase (Activase, rTPA) Amiodarone (Cordarone) Argatroban Atropine Calcium chloride Diltiazem (Cardizem) Dobutamine (Dobutrex) Dopamine Epinephrine (Adrenalin) Esmolol (Brevibloc) Furosemide (Lasix) Heparin Insulin (regular) Lidocaine (Xylocaine) Lorazepam (Ativan) Magnesium Sulfate Reference texts can provide information, but data are often unavailable for new drugs. So is injecting it. wasn't this too much ativan? You are alive to talk about it here. Compatibility of haloperidol and diphenhydramine in a hypodermic syringe Ann Pharmacother. Secondly, if you’re taking Ativan or other lorazepam product, follow the prescription carefully. i was given 5mg haldol, 5mg ativan and 50mg benadryl (diphenhydramine) im for hospital "agitation" i am 60, female, 106lbs. The two drugs are so compatible that you can mix them together in the same syringe. In the ED they tend to be a little quick on the draw with droperidol (can't recall if it's IM or IV). No especially the Ativan & Haldol for both will form a thick white or discolored liquid & not be effective. A Verified Doctor answered. Our version of a B52 is given either orally or IM and consists of Benadryl 50, Haldol 5 and Ativan 2 (if IM, you have to give the benadryl in a separate syringe). Search Recommendations. If a patient is given Halidol, Ativan and Benedryl when they are on Clozaril, Lithium and Depakote, how can you prove the above medications caused the death. 3 doctor answers • 10 doctors weighed in. When you do that, another chemical (acetylcholine) becomes dominant. Tell the doctor about all drugs or herbs being used or considered. It can be frightening for the patient. Share. When there's too much acetylcholine, you get funny stuff like muscle spasms and tremors. Many providers at my institution add 50 mg of diphenhydramine to the syringe, and call the combination a “B-52” for Benadryl + 5 mg haloperidol + 2 mg lorazepam. The first step is to avoid using Ativan without medical supervision. If drugs are mixed together, the Good luck.

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